Nakia Cockatoo and Jake Kolodjashnij are both facing a stint on the sidelines after undergoing surgery in recent days.
Cockatoo has had surgery on his right knee, which he injured against West Coast last weekend.
The surgery involved repairing the lateral ligament.
Cockatoo is likely to be sidelined for six to eight weeks.
Kolodjashnij has required surgery after breaking his hand in a training mishap on Thursday.
He is expected to miss at least two matches.
