Amongst the inclusions are captain Joel Selwood, best and fairest Tom Hawkins, Joel Corey, Paul Chapman and Tom Lonergan.
Also getting their opportunity to play for a spot on the AFL list are rookies Ryan Bathie and Jackson Sheringham who have both come into the side.
A host of Cats who have played in all the Cats previous NAB Cup matches will be rested this week. Jared Rivers, Jimmy Bartel, James Podsiadly and Corey Enright are among them.
The Cats clash with North Melbourne kicks off at 3.40pm at Simonds Stadium.
The full squad:
42 BATHIE Ryan
46 BLICAVS Mark
1 BROWN Mitch
23 CADDY Josh
35 CHAPMAN Paul
28 CHRISTENSEN Allen
11 COREY Joel
37 EARDLEY Cameron
29 GUTHRIE Cameron
45 HAMLING Joel
26 HAWKINS Tom
33 HORLIN-SMITH George
19 HUNT Taylor
20 JOHNSON Steven
9 KELLY James
39 KERSTEN Shane
13 LONERGAN Tom
4 MACKIE Andrew
32 MOTLOP Steven
21 MURDOCH Jordan
15 SCHRODER Jordan
14 SELWOOD Joel
38 SHERINGHAM Jackson
41 STRINGER Jesse
40 THURLOW Jackson
5 VARCOE Travis
34 WALKER Joshua
