Star midfielder Cameron Guthrie is set to miss Sunday's clash with North Melbourne at Etihad Stadium.

Guthrie was initially named in the team to play Fremantle last weekend, but withdrew two days before the match due to calf soreness.

Now he seems like to miss another game.

“It’s still early in our preparation, so it’s hard to get clarity,” Cats coach Chris Scott said during his weekly press conference at Simonds Stadium on Wednesday.

“But, one thing's for sure, we will be really conservative with him.

“He’s had a couple of minor issues. It’s two in a month now.

“We would treat all our players cautiously in these circumstances, but he’s been a very, very good player for us and we need to make sure when he comes back he’s ready to perform at 100 per cent.

“Now that involves conditioning as well given he’s missed a fair portion of training.”