Harry Taylor, Mark Blicavs, Steven Motlop, Josh Caddy and Taylor Hunt come into the side that beat Greater Western Sydney before the bye.
See Scott Gullan and James Kelly discuss how to beat the Lions
Trent West (back) and Mitch Brown (omitted) are the only outs so far to the Cats squad with the team to be finalised on Friday afternoon.
The Cats have only lost to the Lions once since 2005 with an average winning margin of 51.7 points. Overall the Cats have won seven of their 14 games at the GABBA.
Read the official Cats v Lions preview.
Cats squad:
B: Enright, Lonergan, Guthrie
HB: Corey, Taylor, J Hunt
C: Mackie, Selwood, Kelly
HF: Blicavs, Podsiadly, Christensen
F: Duncan, Hawkins, Motlop
R: Vardy, Johnson, Bartel
IC: Caddy, Stokes, T Hunt, Murdoch, Stringer, Smedts, Thurlow
